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MILESTONE SCIENTIFIC TO ESTABLISH JOINT VENTURE TO DEVELOP MEDICAL DRUG DELIVERY INSTRUMENTS

Piscataway, N.J. – (PR NEWSWIRE) – December 3, 2009 – Milestone Scientific Inc. (OTCBB:MLSS), the recognized leader in advanced injection technologies, today announced that it had entered into a joint venture with China National Medicines Corporation Ltd. (d/b/a “Sinopharm”) and Yichang Humanwell Pharmaceutical Co. Ltd., both incorporated in the People’s Republic of China (the “PRC”), to develop orthopedic and epidural drug delivery instruments.  Under an “Agreement of Intent,” Milestone and its two PRC joint venture partners will establish a new joint venture entity for this purpose in the first quarter of 2010.  The required initial funding for the new entity, estimated by the parties at $1.4 million, will be provided by the two PRC companies, although Milestone will determine the proposed uses of their contribution.  The joint venture entity will utilize and adapt Milestone’s proprietary, patented CompuFlo® technology for use in orthopedic and epidural drug delivery instruments.  Milestone will own 50% of the joint venture entity and the PRC parties will together own the remaining 50%.

Leonard Osser, Chief Executive Officer of Milestone stated, “This new joint venture with two leading PRC pharmaceutical companies marks a significant step forward in Milestone’s efforts to have its innovative computer-controlled drug delivery technology adapted for medical usage worldwide. Preliminary studies have shown the effectiveness of using our CompuFlo technology for the alleviation of the pain associated with arthritic joint conditions and in providing accurate and more efficacious epidural anesthetic injections.  With the help of our PRC partners, we believe that our CompuFlo technology can be developed and marketed for these potentially large medical markets.”

Traded on the Shanghai Stock Exchange (SHA:600511), China National Medicines Corporation, d/b/a Sinopharm, is China’s largest domestic manufacturer, distributor and marketer of pharmaceuticals and importer of medical devices.

Yichang Humanwell Pharmaceutical Co. Ltd. is a major nationally designated anesthetics manufacturer in the PRC.  It maintains a major R&D center with strong research and development capability and has established relationships with a number of PRC universities, including China Pharmaceutical University, Peking University Health Science Center, Huaxi Medical University, and Hua Zhong University of Science and Technology Tongji Medical College.

Milestone’s patented CompuFlo is a computer-controlled injection delivery technology that uses Dynamic Pressure Sensing® (DPS) for painless delivery and aspiration of all medicaments. The DPS provides visual and audible in-tissue pressure feedback, identifying tissue types to the healthcare provider.  This feedback allows the healthcare provider to know when certain types of tissue have been penetrated, allowing for the injection of medicaments at a precise location.  This is particularly beneficial when making subcutaneous and intramuscular injections.

About Milestone Scientific Inc.
Headquartered in Piscataway, New Jersey, Milestone Scientific is engaged in pioneering proprietary, highly innovative technological solutions for the medical and dental markets.  Central to the Company’s IP platform and product development strategy is its patented CompuFlo® technology for the improved and painless delivery of local anesthetic.  Specifically, CompuFlo is a computer-controlled, pressure sensitive infusion, perfusion, suffusion and aspiration technology, which provides real-time readouts of pressures, fluid densities and flow rates, enabling the advanced delivery and removal of a wide array of fluids.  The STA Single Tooth Anesthesia System™, a computer-controlled local anesthesia delivery system, uses this technology to provide dentists with audible and visual signals as to in-tissue pressure.  Milestone’s existing painless injection systems are currently sold in 25 countries.  For more information on these and other innovative Milestone products, please visit the Company’s web site found at www.milestonescientific.com and www.STAis4U.com.

FOR MORE INFORMATION, PLEASE CONTACT:
Elite Financial Communications Group
Dodi Handy, President and CEO
For Media Inquiries: Tiffany Korkis or Kathy Addison, Directors, Elite Media Group
407-585-1080 or via email at mlss@efcg.net


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